Table 5.
Unadjusted and multivariate linear regression of ln (ACR) and serum creatinine for Enh 2 in all genotyped European Americans, by type 2 diabetes status.
| Regression coefficient forGLUT1 Enh2 Risk Genotype(TT) (95% CI) reference: (CC or CT) | ||||
|---|---|---|---|---|
| (N = Enh2 TT Genotype/All Genotypes) | ln (ACR) ß Coefficient (95% CI) | P-value | Serum Creatinine ß Coefficient (95% CI) | P-value |
| TYPE 2 DIABETES (N = 72/1,095) | ||||
| Unadjusted | 0.26 (-0.17 - 0.69) | 0.240 | 0.06 (-0.00 - 0.13) | 0.069 |
| Model 1 | 0.27 (-0.14 - 0.68) | 0.196 | 0.02 (-0.04 - 0.09) | 0.446 |
| Model 2 | 0.28 (-0.13 - 0.68) | 0.185 | 0.02 (-0.04 - 0.09) | 0.446 |
| NON-DIABETIC (N = 478/7,027) | ||||
| Unadjusted | -0.02 (-0.12 - 0.09) | 0.737 | -0.01 (-0.04 - 0.01) | 0.189 |
| Model 1 | -0.02 (-0.12 - 0.08) | 0.702 | -0.01 (-0.03 - 0.01) | 0.146 |
| Model 2 | -0.02 (-0.12 - 0.08) | 0.667 | -0.01 (-0.03 - 0.00) | 0.143 |
Model 1 includes age, sex, systolic blood pressure, diastolic blood pressure and hypertension medication use.
Model 2 includes Model 1 covariates and BMI and estimated glomerular filtration rate for the outcome ln (ACR). For the outcome of serum creatinine, model 2 includes Model 1 covariates and BMI.