Table 2.
Frequencies of IL-10 Promoter Alleles and Genotype/Haplotypes in Patients With HBV and healthy Control Population
| patients (%) | control (%) | OR | P | |
|---|---|---|---|---|
| Allele | n = 52 × 2 | n = 48 × 2 | ||
| - 1082G | 4(3.9) | 3(3.1) | 1.24 | 0.99 |
| - 1082A | 100(98) | 93(96.8) | 0.81 | 0.99 |
| - 819C | 18(17.3) | 18(18.7) | 0.91 | 0.85 |
| - 819T | 86(92.7) | 78(81.3) | 1.97 | 0.85 |
| 38(36.5) | 22(22.9) | 1.88 | 0.05 | |
| - 592A | 66(63.4) | 74(77.1) | 0.52 | 0.05 |
| Genotype | n = 52 | n = 48 | ||
| - 592 A/A | 23 (44.2) | 30 (62.5) | 0.48 | 0.08 |
| A/C | 20(38.4) | 14(29.2) | 1.52 | 0.40 |
| C/C | 9(17.3) | 4(8.3) | 2.3 | 0.24 |
| - 819T/T | 36(69.2) | 33(68.8) | 1.02 | 0.99 |
| T/C | 12(23.1) | 12(23.1) | 0.9 | 0.99 |
| C/C | 4(7.7) | 4(7.7) | 1.25 | 0.99 |
| - 1082 A/A | 48(92.3) | 45(93.8) | 0.8 | 0.99 |
| A/G | 4(7.7) | 3(6.3) | 1.25 | 0.99 |
| G/G | 0(0) | 0(0) | ||
| Heplotype(-1082/-819/-592) | ||||
| n = 52 | n = 48 | |||
| GCC | 4 (7.6) | 3(6.2) | 1.25 | 0.99 |
| ACC | 13 (25) | 14(29.1) | 0.81 | 0.66 |
| ATA | 41 (78.8) | 43(89.5) | 0.43 | 0.18 |
| GTA | 2 (3.8) | 2(4.1) | 0.92 | 0.99 |
NOTE: n is the number of patients or controllers. P values were caculated by Fisher Probability. P values less than 0.05 were considered statistically significant. SR: sustained response; NR: non-responders.