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. 2011 Jan 13;10:7. doi: 10.1186/1476-4598-10-7

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Copyright ©2011 Allegrucci et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of epigenetic reprogramming on in vivo tumorigenicity. Macroscopic and microscopic analyses of tumour xenografts. (A) Macroscopic appearance of untreated (UN) and AOE-treated tumour xenografts (AOE) and relative tumour growth curves (* indicates P < 0.05). (B) Eosin-Haematoxylin staining of untreated tumour sections (black arrows: mitotic figures; Bar = 50 μm). (C) Number of mitotic figures for two independent tumours in untreated (UN) and AOE-treated xenografts (AOE) (* indicates P < 0.05). (D) Interstitial stroma present in AOE-treated tumours stained for collagen (blue staining; Bar = 50 μm).