Table 2. PKCδ overexpression amplifies the genotoxic effects of etoposide.

		SH-SY-5Y
		Standard (A.U.)	fpg (A.U.)
CTR	EV	0.0006±0.0001	0.0004±0.0001
	PKC δ	0.0006±0.0001	12.111±4.632**,°°
BSO	EV	0.0005±0.0001	0.0005±0.0001
	PKC δ	20.4718±3.9458§§	17.5194±3.9908§§
ETOPO	EV	0.0004±0.0001	9.0121±3.5361**,§§
	PKC δ	22.0825±4.1479§§	16.1373±3.5423§§
ROT	EV	0.0004±0.0002	0.0004±0.0001
	PKC δ	0.0005±0.0002	0.0003±0.0001••
ROT+BSO	EV	0.0004±0.0001	0.0003±0.0001
	PKC δ	0.0004±0.0001◊◊	0.0003±0.0002◊◊
ROT+ETOPO	EV	0.0005±0.0003	0.0002±0.0001##
	PKC δ	0.0003±0.0002◊◊	0.0003±0.0002◊◊

SH-SY-5Y cells, transiently transfected with empty vector (EV) or PKCδ plasmid, were treated with 0.07 µM etoposide or 1 mM BSO for 24 h. Where indicated, cells were pre-treated with rottlerin for 30 min. DNA fragmentation (standard) and oxidation (fpg) were evaluated by comet test. The reported values derive from tail moment analyses.

**p<0.01 vs EV CTR/fpg;

°°p<0.01 vs PKCδ CTR standard;

^§§ p<0.01 vs EV + BSO/ETOPO;

^## p<0.01 vs EV ETOPO fpg;

^•• p<0.01 vs PKCδ CTR fpg;

^◊◊ p<0.01 vs PKCδ+BSO/ETOPO.