Table 3. Silencing of PKCδ prevents the genotoxic effects triggered by etoposide and BSO in SH-SY-5Y and in SK-N-BE-2C cells, respectively.

		SH-SY-5Y		SK-N-BE-2C
		standard (A.U.)	fpg (A.U.)	Standard (A.U.)	fpg (A.U.)
CTR	NoT	0.0006±0.0001	0.0004±0.0001	0.0008±0.0001	0.0006±0.0001
	siPKCδ	0.0006±0.0001	0.0007±0.0001	0.0009±0.0001	0.0008±0.0001
ETOPO	NoT	0.0004±0.0001	8.352±2.8754**,§§	-	-
	siPKCδ	0.0006±0.0001	0.0004±0.0001##	-	-
BSO	NoT	-	-	11.325±2.184♦♦	13.215±1.969**
	siPKCδ	-	-	0.0007±0.0001§§	0.0006±0.0001##

NB cells, silenced for PKCδ, were treated with 0.07 µM etoposide (SH-SY-5Y) and 1 mM BSO (SK-N-BE-2C) for 24 h. DNA fragmentation (standard) and oxidation (fpg) were evaluated by comet test. The reported values derive from tail moment analyses.

**p<0.01 vs NoT CTR fpg;

^♦♦ p<0.01 vs NoT CTR standard;

^§§ p<0.01 vs NoT + ETOPO/BSO standard,

^## p<0.01 vs NoT ETOPO/BSO fpg.