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. Author manuscript; available in PMC: 2011 Feb 7.
Published in final edited form as: Chem Biol. 2009 Oct 30;16(10):1045–1052. doi: 10.1016/j.chembiol.2009.09.012

Figure 4. Effect of cysteine mutations on MGL inhibition by pristimerin and euphol.

Figure 4

Effects of mutating Cys201 or Cys208 on MGL inhibition by pristimerin (A) and euphol (B). Concentration-response curves for the inhibition of wild-type MGL (wt, squares) and MGL mutants containing cysteine-to-glycine mutations at either Cys201 (C201G, triangles) or Cys208 (C208G, circles). Enzyme activity is reported as percent of vehicle controls (DMSO, 1%). Results are expressed as mean ± SEM (n = 4-9). P<0.0001, ANOVA, followed by Dunnett's test.