Figure 5. Pristimerin protects 2-AG from degradation in neurons.
Effects of pristimerin (1 μM), NAM (1 μM) or vehicle (0.1% DMSO in DMEM) in primary cultures of rat cortical neurons. Levels of 2-AG and PEA are reported as fold change over vehicle-treated neurons. Results are expressed as mean ± SEM (n=5). ****P<0.0001, ***P<0.001, *P<0.05, ns = not significant, unpaired Student's t-test.