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. Author manuscript; available in PMC: 2011 Feb 7.
Published in final edited form as: Chem Biol. 2009 Oct 30;16(10):1045–1052. doi: 10.1016/j.chembiol.2009.09.012

TABLE 1. Inhibition of Purified Recombinant MGL by Friedelane-Based Pentacyclic Triterpenoids.

Compound Structure IC50
1 Pristimerin graphic file with name nihms150490t1.jpg 93 ± 8 nM
2 Celastrol graphic file with name nihms150490t2.jpg 1.6 ± 0.4 μM
3 Pristimerol graphic file with name nihms150490t3.jpg 4 ± 0.5 μM
4 Dihydrocelastrol graphic file with name nihms150490t4.jpg 15 ± 4 μM
5 Dihydrocelastryl Diacetate graphic file with name nihms150490t5.jpg 15 ± 3 μM

Results are expressed as mean ± SEM (n = 3-4)