Table III.
Aqueous Pores in all of the Tested PAMPA Models a
| Compound | Stir | log PABL | SD | n | log Ppara | SD | n | (ε/δ)2 | SD | Vlipid (μL) | δ (cm) | ε |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BD Pre-Coated | no | −4.80 | 0.20 | 16 | −5.42 | 0.47 | 14 | 1.19 | 1.39 | 1.0 | 0.0071 | 0.0084 |
| Type I | no | −4.30 | 0.24 | 4 | −6.51 | 1.07 | 9 | 0.33 | 0.46 | 1.5 | 0.0087 | 0.0029 |
| Type II | no | −4.63 | 0.29 | 11 | −7.12 | 0.41 | 13 | 0.027 | 0.027 | 3.0 | 0.0137 | 0.0004 |
| Type I | yes | −3.17 | 0.16 | 18 | −6.09 | 0.68 | 26 | 0.38 | 0.48 | 1.5 | 0.0087 | 0.0033 |
| Type II | yes | −3.30 | 0.30 | 45 | −6.13 | 0.57 | 50 | 0.34 | 0.72 | 3.0 | 0.0137 | 0.0047 |
a
See Abbreviations for definitions. The permeability coefficients were averaged from refined results. Stirring speed was set in the Gut-Box (pION) to produce about 60 μm ABL thicknesses. The Type I and II plates contained the sink-forming pH 7.4 buffer in the receiver wells (see text). The BD pre-coated plates used a pH 7.4 sink-additive-free buffer in the receiving wells, and thus show more ABL permeation resistance than those of Type I/II.