Table V.
In Situ Brain Perfusion Data Refinement Results a
| PS (10−4 mLg−1s−1) | log PS | Efflux Inhibition | Ref | log Poin situ (obs) | log Poin situ (calc) | obs–calc | |
|---|---|---|---|---|---|---|---|
| Training set | |||||||
| Amitriptyline | 891 | −1.05 | (35) | −1.52 | −1.21 | −0.3 | |
| Amitriptyline | 1096 | −0.96 | (11) | −1.43 | −1.21 | −0.2 | |
| Amitriptyline | 2187 | −0.66 | mdr1a(−/−) | (11) | −1.13 | −1.21 | 0.1 |
| Amoxapine | 657 | −1.18 | (35) | −2.77 | −2.35 | −0.4 | |
| Astemizole | 246 | −1.61 | (11) | −2.66 | −1.41 | −1.3 | |
| Astemizole | 282 | −1.55 | mdr1a(−/−) | (11) | −2.61 | −1.41 | −1.2 |
| Atomoxetine | 407 | −1.39 | (35) | −1.28 | −1.82 | 0.5 | |
| Bremazocine | 129 | −1.89 | mdr1a(−/−) | (51) | −2.76 | −3.19 | 0.4 |
| Bremazocine | 81 | −2.09 | (51) | −2.96 | −3.19 | 0.2 | |
| Buspirone | 1142 | −0.94 | mdr1a(−/−) | (11) | −2.53 | −3.64 | 1.1 |
| Buspirone | 1018 | −0.99 | (11) | −2.58 | −3.64 | 1.1 | |
| Carbamazepine | 178 | −1.75 | (35) | −3.75 | −3.83 | 0.1 | |
| Carbamazepine | 478 | −1.32 | (11) | −3.32 | −3.83 | 0.5 | |
| Carbamazepine | 549 | −1.26 | mdr1a(−/−) | (11) | −3.26 | −3.83 | 0.6 |
| Cetirizine | 2 | −3.73 | CsA | (52) | −5.61 | −5.69 | 0.1 |
| Chlorambucil | 250 | −1.60 | (53) | −0.80 | −1.06 | 0.3 | |
| Chlorpromazine | 631 | −1.20 | (35) | −1.36 | −1.39 | 0.0 | |
| Chlorpromazine | 831 | −1.08 | mdr1a(−/−) | (11) | −1.23 | −1.39 | 0.2 |
| Chlorpromazine | 871 | −1.06 | (11) | −1.22 | −1.39 | 0.2 | |
| Cimetidine | 1 | −4.10 | (32) | −5.97 | −5.58 | −0.4 | |
| Cimetidine | 1 | −4.08 | bcrp(−/−) | (36) | −5.95 | −5.58 | −0.4 |
| Cimetidine | 1 | −4.05 | (32) | −5.92 | −5.58 | −0.4 | |
| Cimetidine | 1 | −3.93 | (45) | −5.81 | −5.58 | −0.2 | |
| Cimetidine | 1 | −3.87 | (36) | −5.75 | −5.58 | −0.2 | |
| Cimetidine | 2 | −3.74 | mdr1a(−/−) | (45) | −5.61 | −5.58 | 0.0 |
| Citalopram | 103 | −1.99 | (35) | −2.07 | −1.98 | −0.1 | |
| Clozapine | 187 | −1.73 | mdr1a(−/−) | (11) | −3.11 | −2.56 | −0.5 |
| Clozapine | 263 | −1.58 | (11) | −2.96 | −2.56 | −0.4 | |
| Clozapine | 514 | −1.29 | (35) | −2.67 | −2.56 | −0.1 | |
| Codeine | 33 | −2.48 | (54) | −3.80 | −3.63 | −0.2 | |
| Colchicine | 1 | −3.83 | (55) | −5.83 | −5.43 | −0.4 | |
| Colchicine | 2 | −3.82 | (45) | −5.82 | −5.43 | −0.4 | |
| Colchicine | 3 | −3.59 | (56) | −5.59 | −5.43 | −0.1 | |
| Colchicine | 3 | −3.59 | (33) | −5.59 | −5.43 | −0.1 | |
| Colchicine | 3 | −3.55 | (57) | −5.55 | −5.43 | −0.1 | |
| Colchicine | 6 | −3.20 | mdr1a(−/−) | (45) | −5.50 | −5.43 | −0.1 |
| Colchicine | 5 | −3.30 | (53) | −5.30 | −5.43 | 0.1 | |
| Colchicine | 6 | −3.24 | PSC833 | (58) | −5.24 | −5.43 | 0.2 |
| Colchicine | 7 | −3.14 | mdr1a(−/−) | (57) | −5.14 | −5.43 | 0.3 |
| Colchicine | 8 | −3.12 | mdr1a(−/−) | (56) | −5.12 | −5.43 | 0.3 |
| Colchicine | 9 | −3.06 | PSC833 | (33) | −5.06 | −5.43 | 0.4 |
| Colchicine | 12 | −2.91 | GF120918 | (55) | −4.91 | −5.43 | 0.5 |
| Colchicine | 17 | −2.78 | PSC833 | (55) | −4.78 | −5.43 | 0.7 |
| Corticosterone | 51 | −2.29 | (59) | −4.29 | −4.25 | 0.0 | |
| Daunomycin | 20 | −2.70 | (53) | −2.40 | −3.17 | 0.8 | |
| Deltorphin II | 0.4 | −4.36 | mdr1a(−/−) | (51) | −6.36 | −6.48 | 0.0 |
| Deltorphin II | 0.3 | −4.56 | (51) | −6.56 | −6.48 | −0.2 | |
| Diazepam | 199 | −1.70 | (60) | −3.70 | −3.27 | −0.4 | |
| Diazepam | 214 | −1.67 | (30) | −3.67 | −3.27 | −0.4 | |
| Diazepam | 426 | −1.37 | (35) | −3.37 | −3.27 | −0.1 | |
| Diazepam | 589 | −1.23 | mdr1a(−/−) | (45) | −3.23 | −3.27 | 0.0 |
| Diazepam | 589 | −1.23 | mdr1a(−/−) | (45) | −3.23 | −3.27 | 0.0 |
| Diazepam | 645 | −1.19 | mdr1a(−/−) | (31) | −3.19 | −3.27 | 0.1 |
| Diazepam | 977 | −1.01 | (61) | −3.01 | −3.27 | 0.3 | |
| Diltiazem | 125 | −1.90 | (11) | −3.19 | −3.01 | −0.2 | |
| Diltiazem | 300 | −1.52 | mdr1a(−/−) | (11) | −2.81 | −3.01 | 0.2 |
| Diphenhydramine | 616 | −1.21 | CsA | (52) | −1.90 | −2.50 | 0.6 |
| Diphenhydramine | 525 | −1.28 | (52) | −1.97 | −2.50 | 0.5 | |
| Dipyridamole | 26 | −2.59 | bcrp(−/−) | (36) | −4.59 | −4.33 | −0.3 |
| Dipyridamole | 35 | −2.46 | (36) | −4.46 | −4.33 | −0.2 | |
| Domperidone | 16 | −2.79 | mdr1a(−/−) | (11) | −4.01 | −3.64 | −0.4 |
| Doxepin | 493 | −1.31 | (35) | −1.26 | −1.52 | 0.3 | |
| DPDPE | 1 | −3.97 | mdr1a(−/−) | (51) | −5.97 | −6.11 | 0.1 |
| Ergotamine | 87 | −2.06 | (35) | −3.82 | −3.96 | 0.1 | |
| Ethosuximide | 34 | −2.47 | (35) | −4.46 | −4.63 | 0.2 | |
| Etoposide | 1 | −4.05 | (62) | −6.05 | −5.98 | −0.1 | |
| Etoposide | 1 | −3.91 | mdr1a(−/−) | (62) | −5.91 | −5.98 | 0.1 |
| Fentanyl | 955 | −1.02 | mdr1a(−/−) | (51) | −2.24 | −3.05 | 0.8 |
| Fentanyl | 549 | −1.26 | (51) | −2.49 | −3.05 | 0.6 | |
| Fexofenadine | 1 | −4.08 | CsA | (52) | −5.94 | −5.48 | −0.5 |
| Fexofenadine | 2 | −3.66 | mdr1a(−/−) | (45) | −5.53 | −5.48 | 0.0 |
| Fluoxetine | 314 | −1.50 | (53) | −1.28 | −1.41 | 0.1 | |
| Fluoxetine | 656 | −1.18 | (35) | −0.96 | −1.41 | 0.5 | |
| Flurbiprofen | 158 | −1.80 | not satbl | (63) | −0.58 | −0.58 | 0.0 |
| Fluvastatin Acid | 4 | −3.38 | (83) | −2.28 | −3.14 | 0.9 | |
| Galanthamine | 33 | −2.48 | (11) | −3.24 | −3.43 | 0.2 | |
| Galanthamine | 35 | −2.46 | mdr1a(−/−) | (11) | −3.21 | −3.43 | 0.2 |
| Glibenclamide | 5 | −3.27 | (32) | −3.74 | −2.83 | −0.9 | |
| Glibenclamide | 17 | −2.77 | (32) | −3.24 | −2.83 | −0.4 | |
| Haloperidol | 347 | −1.46 | (35) | −2.47 | −2.15 | −0.3 | |
| Hydroxyzine | 393 | −1.41 | CsA | (52) | −3.04 | −3.64 | 0.6 |
| Hydroxyzine | 441 | −1.36 | (52) | −2.99 | −3.64 | 0.7 | |
| Ibuprofen | 93 | −2.03 | Kd | (63) | −1.22 | −1.09 | −0.1 |
| Imatinib | 78 | −2.11 | mdr1a(−/−) | (64) | −3.70 | −3.95 | 0.3 |
| Indinavir | 4 | −3.40 | mdr1a(−/−) | (11) | −5.37 | −5.68 | 0.3 |
| Indomethacin | 7 | −3.18 | not satbl | (65) | −2.08 | −1.59 | −0.5 |
| Indomethacin | 6 | −3.21 | not satbl | (65) | −2.08 | −1.59 | −0.5 |
| Indomethacin | 65 | −2.19 | not satbl | (63) | −1.06 | −1.59 | 0.5 |
| Lidocaine | 126 | −1.90 | (66) | −3.24 | −3.62 | 0.4 | |
| Loperamide | 219 | −1.66 | mdr1a(−/−) | (51) | −2.52 | −2.73 | 0.2 |
| Lovastatin Acid | 2 | −3.63 | (83) | −2.53 | −3.34 | 0.8 | |
| Maprotiline | 426 | −1.37 | (35) | −0.41 | −0.62 | 0.2 | |
| Melphalan | 5 | −3.28 | Kd | (67) | −5.27 | −5.23 | 0.0 |
| Meperidine | 525 | −1.28 | mdr1a(−/−) | (51) | −2.08 | −1.60 | −0.5 |
| Meperidine | 549 | −1.26 | (51) | −2.05 | −1.60 | −0.5 | |
| Methadone | 234 | −1.63 | mdr1a(−/−) | (51) | −2.02 | −2.07 | 0.0 |
| Mirtazapine | 403 | −1.39 | (35) | −2.76 | −2.58 | −0.2 | |
| Morphine | 1 | −4.23 | not satbl | (68) | −5.43 | −4.55 | −0.9 |
| Morphine | 2 | −3.76 | (69) | −4.96 | −4.55 | −0.4 | |
| Morphine | 2 | −3.76 | (51) | −4.96 | −4.55 | −0.4 | |
| Morphine | 2 | −3.68 | (57) | −4.87 | −4.55 | −0.3 | |
| Morphine | 2 | −3.66 | mdr1a(−/−) | (69) | −4.86 | −4.55 | −0.3 |
| Morphine | 2 | −3.67 | mdr1a(−/−) | (51) | −4.86 | −4.55 | −0.3 |
| Morphine | 2 | −3.64 | (33) | −4.84 | −4.55 | −0.3 | |
| Morphine | 3 | −3.51 | mdr1a(−/−) | (33) | −4.70 | −4.55 | −0.2 |
| Morphine | 3 | −3.49 | mdr1a(−/−) | (57) | −4.69 | −4.55 | −0.1 |
| Morphine | 5 | −3.30 | (54) | −4.50 | −4.55 | 0.0 | |
| Morphine | 20 | −2.70 | (53) | −3.90 | −4.55 | 0.6 | |
| Naltrindole | 104 | −1.98 | mdr1a(−/−) | (51) | −3.03 | −2.64 | −0.4 |
| Naproxen | 68 | −2.17 | (70) | −0.77 | −1.23 | 0.5 | |
| Naringenin | 105 | −1.98 | PSC833 | (55) | −3.96 | −3.96 | 0.0 |
| Oxycodone | 13 | −2.87 | pyrilamine | (71) | −3.59 | −3.29 | −0.3 |
| Oxycodone | 18 | −2.75 | pyrilamine | (71) | −3.48 | −3.29 | −0.2 |
| Oxycodone | 25 | −2.61 | (71) | −3.34 | −3.29 | −0.1 | |
| Oxycodone | 37 | −2.43 | (71) | −3.15 | −3.29 | 0.1 | |
| Pergolide | 1000 | −1.00 | (35) | −1.19 | −1.58 | 0.4 | |
| p-F-Phenylalanine(D) | 14 | −2.85 | (11) | −4.84 | −4.97 | 0.1 | |
| p-F-Phenylalanine(D) | 15 | −2.82 | mdr1a(−/−) | (11) | −4.81 | −4.97 | 0.1 |
| Phenytoin | 50 | −2.30 | (54) | −4.26 | −3.83 | −0.4 | |
| Phenytoin | 60 | −2.22 | (45) | −4.18 | −3.83 | −0.4 | |
| Phenytoin | 62 | −2.21 | mdr1a(−/−) | (45) | −4.16 | −3.83 | −0.3 |
| Phenytoin | 63 | −2.20 | (53) | −4.15 | −3.83 | −0.3 | |
| Phenytoin | 85 | −2.07 | (35) | −4.02 | −3.83 | −0.2 | |
| Prazosin | 10 | −3.02 | (72) | −4.83 | −4.27 | −0.6 | |
| Prazosin | 28 | −2.55 | prazosin 30uM | (72) | −4.36 | −4.27 | −0.1 |
| Probenecid | 0.1 | −4.94 | (11) | −2.70 | −1.96 | −0.7 | |
| Probenecid | 0.2 | −4.79 | mdr1a(−/−) | (11) | −2.55 | −1.96 | −0.6 |
| Propranolol | 111 | −1.95 | (54) | −2.17 | −2.02 | −0.2 | |
| Propranolol | 625 | −1.20 | (53) | −1.42 | −2.02 | 0.6 | |
| Propranolol | 741 | −1.13 | (61) | −1.35 | −2.02 | 0.7 | |
| Propranolol | 1584 | −0.80 | (73) | −1.02 | −2.02 | 1.0 | |
| Pyrilamine | 49 | −2.31 | Kd | (74) | −2.89 | −2.49 | −0.4 |
| Quercetin | 22 | −2.65 | GF120918 | (55) | −4.03 | −4.72 | 0.7 |
| Quinidine | 18 | −2.74 | (32) | −3.56 | −2.85 | −0.7 | |
| Quinidine | 22 | −2.66 | GF120918 | (75) | −3.48 | −2.85 | −0.6 |
| Quinidine | 74 | −2.13 | mdr1a(−/−) | (69) | −2.95 | −2.85 | −0.1 |
| Quinidine | 102 | −1.99 | mdr1a(−/−) | (45) | −2.82 | −2.85 | 0.0 |
| Ritonavir | 13 | −2.87 | mdr1a(−/−) | (45) | −4.87 | −4.84 | 0.0 |
| Ritonavir | 26 | −2.59 | mdr1a(−/−) | (11) | −4.59 | −4.84 | 0.2 |
| S-145 | 23 | −2.63 | (30) | −2.13 | −2.86 | 0.7 | |
| Salicylic Acid | 4 | −3.40 | (53) | −1.02 | −1.88 | 0.9 | |
| Saquinavir | 19 | −2.73 | mdr1a(−/−) | (11) | −4.63 | −5.18 | 0.5 |
| Sertraline | 467 | −1.33 | CsA | (65) | −1.87 | −1.73 | −0.1 |
| Sertraline | 691 | −1.16 | (11) | −1.69 | −1.73 | 0.0 | |
| Sertraline | 741 | −1.13 | mdr1a(−/−) | (11) | −1.67 | −1.73 | 0.1 |
| Sertraline | 1949 | −0.71 | (35) | −1.24 | −1.73 | 0.5 | |
| SNC121 | 363 | −1.44 | mdr1a(−/−) | (51) | −2.96 | −2.76 | −0.2 |
| Terfenadine | 288 | −1.54 | (11) | −1.08 | −0.93 | −0.1 | |
| Terfenadine | 302 | −1.52 | mdr1a(−/−) | (11) | −1.06 | −0.93 | −0.1 |
| Terfenadine | 407 | −1.39 | CsA | (52) | −0.92 | −0.93 | 0.0 |
| Terfenadine | 490 | −1.31 | (45) | −0.85 | −0.93 | 0.1 | |
| Terfenadine | 562 | −1.25 | (76) | −0.79 | −0.93 | 0.2 | |
| Terfenadine | 616 | −1.21 | mdr1a(−/−) | (76) | −0.75 | −0.93 | 0.2 |
| Terfenadine | 660 | −1.18 | mdr1a(−/−) | (45) | −0.71 | −0.93 | 0.2 |
| Theophylline | 5 | −3.31 | (61) | −5.29 | −5.16 | −0.1 | |
| Theophylline | 6 | −3.26 | (32) | −5.24 | −5.16 | −0.1 | |
| Theophylline | 13 | −2.90 | (53) | −4.88 | −5.16 | 0.3 | |
| Theophylline | 15 | −2.81 | (32) | −4.79 | −5.16 | 0.4 | |
| Thioridazine | 426 | −1.37 | (35) | −1.97 | −1.21 | −0.8 | |
| Tolbutamide | 2 | −3.82 | (11) | −3.62 | −2.87 | −0.8 | |
| Tolbutamide | 2 | −3.74 | mdr1a(−/−) | (11) | −3.53 | −2.87 | −0.7 |
| Tolbutamide | 14 | −2.85 | (32) | −2.64 | −2.87 | 0.2 | |
| Tolbutamide | 25 | −2.60 | (32) | −2.40 | −2.87 | 0.5 | |
| Trazodone | 334 | −1.48 | (35) | −3.14 | −3.10 | 0.0 | |
| U69593 | 71 | −2.15 | (51) | −2.24 | −2.12 | −0.1 | |
| U69593 | 98 | −2.01 | mdr1a(−/−) | (51) | −2.10 | −2.12 | 0.0 |
| Valproic Acid | 59 | −2.23 | (85) | −2.74 | −2.34 | −0.4 | |
| Valproic Acid | 68 | −2.17 | (32) | −2.67 | −2.34 | −0.3 | |
| Valproic Acid | 93 | −2.03 | Kd | (86) | −2.54 | −2.34 | −0.2 |
| Valproic Acid | 100 | −2.00 | (53) | −2.50 | −2.34 | −0.2 | |
| Valproic Acid | 100 | −2.00 | mdr1a(−/−) | (45) | −2.50 | −2.34 | −0.2 |
| Valproic Acid | 135 | −1.87 | (45) | −2.37 | −2.34 | 0.0 | |
| Valproic Acid | 240 | −1.62 | (32) | −2.12 | −2.34 | 0.2 | |
| Venlafaxine | 104 | −1.98 | (35) | −1.66 | −2.26 | 0.6 | |
| Verapamil | 331 | −1.48 | mdr1a(−/−) | (45) | −2.26 | −1.93 | −0.3 |
| Verapamil | 381 | −1.42 | mdr1a(−/−) | (56) | −2.20 | −1.93 | −0.3 |
| Verapamil | 467 | −1.33 | mdr1a(−/−) | (69) | −2.10 | −1.93 | −0.2 |
| Vinblastine | 3 | −3.60 | (72) | −5.29 | −5.16 | −0.1 | |
| Vinblastine | 3 | −3.60 | (57) | −5.29 | −5.16 | −0.1 | |
| Vinblastine | 3 | −3.59 | (33) | −5.28 | −5.16 | −0.1 | |
| Vinblastine | 3 | −3.49 | (32) | −5.18 | −5.16 | 0.0 | |
| Vinblastine | 4 | −3.37 | PSC833 | (58) | −5.06 | −5.16 | 0.1 |
| Vinblastine | 5 | −3.32 | (32) | −5.01 | −5.16 | 0.2 | |
| Vinblastine | 5 | −3.31 | mdr1a(−/−) | (57) | −5.00 | −5.16 | 0.2 |
| Vinblastine | 5 | −3.27 | (77) | −4.96 | −5.16 | 0.2 | |
| Vinblastine | 6 | −3.25 | GF120918 | (72) | −4.94 | −5.16 | 0.2 |
| Vinblastine | 8 | −3.12 | mdr1a(−/−) | (33) | −4.81 | −5.16 | 0.4 |
| Vincristine | 1 | −4.25 | mrp1(−/−) | (62) | −5.95 | −5.38 | −0.5 |
| Vincristine | 1 | −4.19 | (19) | −5.89 | −5.38 | −0.5 | |
| Vincristine | 1 | −4.12 | (32) | −5.82 | −5.38 | −0.4 | |
| Vincristine | 1 | −4.00 | (54) | −5.70 | −5.38 | −0.3 | |
| Vincristine | 1 | −3.90 | (33) | −5.60 | −5.38 | −0.2 | |
| Vincristine | 1 | −3.91 | (77) | −5.60 | −5.38 | −0.2 | |
| Vincristine | 2 | −3.82 | mdr1a(−/−) | (33) | −5.52 | −5.38 | −0.1 |
| Vincristine | 8 | −3.10 | (32) | −4.79 | −5.38 | 0.6 | |
| Warfarin | 79 | −2.10 | (32) | −1.66 | −2.02 | 0.4 | |
| Warfarin | 102 | −1.99 | (32) | −1.56 | −2.02 | 0.5 | |
| External set | |||||||
| Alfentanil | 602 | −1.22 | (45) | −3.19 | −4.59 | 1.4 | |
| Alfentanil | 977 | −1.01 | mdr1a(−/−) | (45) | −2.98 | −4.59 | 1.6 |
| Antipyrine | 46 | −2.34 | (52) | −4.34 | −4.83 | 0.5 | |
| Antipyrine | 74 | −2.13 | (61) | −4.13 | −4.83 | 0.7 | |
| Antipyrine | 100 | −2.00 | (73) | −4.00 | −4.83 | 0.8 | |
| Antipyrine | 100 | −2.00 | (53) | −4.00 | −4.83 | 0.8 | |
| Antipyrine | 107 | −1.97 | (29) | −3.97 | −4.83 | 0.9 | |
| Antipyrine | 117 | −1.93 | (78) | −3.93 | −4.83 | 0.9 | |
| Antipyrine | 144 | −1.84 | (79) | −3.84 | −4.83 | 1.0 | |
| Antipyrine | 151 | −1.82 | (80) | −3.82 | −4.83 | 1.0 | |
| Antipyrine | 199 | −1.70 | (81) | −3.70 | −4.83 | 1.1 | |
| Bupropion | 304 | −1.52 | (35) | −2.10 | −3.05 | 0.9 | |
| Caffeine | 100 | −2.00 | (53) | −4.00 | −4.68 | 0.7 | |
| Caffeine | 105 | −1.98 | (30) | −3.98 | −4.68 | 0.7 | |
| Caffeine | 186 | −1.73 | (29) | −3.73 | −4.68 | 1.0 | |
| Caffeine | 199 | −1.70 | (81) | −3.70 | −4.68 | 1.0 | |
| Caffeine | 234 | −1.63 | (69) | −3.63 | −4.68 | 1.1 | |
| Cetirizine | 1 | −4.05 | (52) | −5.93 | −5.69 | −0.2 | |
| Cyclosporin A | 7 | −3.14 | (66) | −5.14 | −6.91 | 1.8 | |
| Cyclosporin A | 68 | −2.17 | (32) | −4.17 | −6.91 | 2.7 | |
| Cyclosporin A | 115 | −1.94 | (32) | −3.94 | −6.91 | 3.0 | |
| Digoxin | 0.3 | −4.48 | (32) | −6.48 | −6.87 | 0.4 | |
| Digoxin | 1 | −4.30 | (53) | −6.30 | −6.87 | 0.6 | |
| Digoxin | 1 | −4.14 | (32) | −6.14 | −6.87 | 0.7 | |
| Domperidone | 5 | −3.29 | (11) | −4.51 | −3.64 | −0.9 | |
| Doxorubicin | 0.01 | −5.85 | (19) | −5.55 | −4.75 | −0.8 | |
| Doxorubicin | 2 | −3.66 | mrp1(−/−) | (67) | −3.35 | −4.75 | 1.4 |
| Doxorubicin | 3 | −3.55 | (56) | −3.25 | −4.75 | 1.5 | |
| Doxorubicin | 3 | −3.55 | (33) | −3.25 | −4.75 | 1.5 | |
| Doxorubicin | 4 | −3.44 | verapamil | (82) | −3.14 | −4.75 | 1.6 |
| Doxorubicin | 4 | −3.36 | mdr1a(−/−) | (56) | −3.06 | −4.75 | 1.7 |
| Doxorubicin | 4 | −3.36 | mdr1a(−/−) | (33) | −3.06 | −4.75 | 1.7 |
| DPDPE | 0.1 | −5.04 | (51) | −7.04 | −6.11 | −0.9 | |
| DPDPE | 3 | −3.60 | (53) | −5.60 | −6.11 | 0.5 | |
| Fexofenadine | 0.1 | −5.30 | (52) | −7.17 | −5.48 | −1.7 | |
| Fexofenadine | 0.4 | −4.35 | (45) | −6.21 | −5.48 | −0.7 | |
| Fluphenazine | 135 | −1.87 | (35) | −3.36 | −2.39 | −1.0 | |
| Hydrocortisone | 1 | −3.85 | (59) | −5.85 | −4.82 | −1.1 | |
| Imatinib | 10 | −2.98 | (64) | −4.56 | −3.95 | −0.6 | |
| Indinavir | 1 | −4.06 | (11) | −6.04 | −5.68 | −0.4 | |
| Lamotrigine | 21 | −2.68 | (35) | −4.67 | −3.17 | −1.5 | |
| L-DOPA | 100 | −2.00 | (66) | −3.99 | −4.69 | 0.7 | |
| L-DOPA | 159 | −1.80 | (53) | −3.79 | −4.69 | 0.9 | |
| Loperamide | 17 | −2.77 | (51) | −3.64 | −2.73 | −0.9 | |
| Loxapine | 355 | −1.45 | (35) | −3.37 | −2.66 | −0.7 | |
| Mesoridazine | 153 | −1.82 | (35) | −3.28 | −4.10 | 0.8 | |
| Methadone | 76 | −2.12 | (51) | −2.52 | −2.07 | −0.5 | |
| Methotrexate | 0.3 | −4.49 | (81) | −5.83 | −5.54 | −0.3 | |
| Methotrexate | 1 | −4.23 | (32) | −5.57 | −5.54 | −0.1 | |
| Methotrexate | 1 | −4.17 | (32) | −5.51 | −5.54 | 0.0 | |
| Methotrexate | 3 | −3.60 | (53) | −4.94 | −5.54 | 0.5 | |
| Metoclopramide | 22 | −2.67 | (35) | −2.86 | −1.38 | −1.5 | |
| Naltrindole | 21 | −2.67 | (51) | −3.72 | −2.64 | −1.1 | |
| Paclitaxel | 0.2 | −4.63 | (84) | −6.63 | −4.77 | −1.9 | |
| Perphenazine | 538 | −1.27 | (35) | −2.62 | −1.73 | −0.9 | |
| p-F-Phenylalanine(L) | 295 | −1.53 | (11) | −3.53 | −4.97 | 1.4 | |
| p-F-Phenylalanine(L) | 347 | −1.46 | mdr1a (−/−) | (11) | −3.45 | −4.97 | 1.5 |
| Phenelzine | 21 | −2.67 | (35) | −4.22 | −2.31 | −1.9 | |
| Progesterone | 182 | −1.74 | (59) | −3.74 | −3.11 | −0.6 | |
| Pyrilamine | 282 | −1.55 | (52) | −2.13 | −2.49 | 0.4 | |
| Pyrilamine | 355 | −1.45 | CsA | (52) | −2.04 | −2.49 | 0.4 |
| Quercetin | 2 | −3.77 | (55) | −5.15 | −4.72 | −0.4 | |
| Quercetin | 2 | −3.67 | PSC833 | (55) | −5.04 | −4.72 | −0.3 |
| Quetiapine | 467 | −1.33 | (35) | −3.07 | −3.27 | 0.2 | |
| Quinidine | 2 | −3.68 | (75) | −4.50 | −2.85 | −1.7 | |
| Quinidine | 4 | −3.40 | (53) | −4.22 | −2.85 | −1.4 | |
| Quinidine | 5 | −3.32 | (69) | −4.14 | −2.85 | −1.3 | |
| Quinidine | 6 | −3.24 | (45) | −4.07 | −2.85 | −1.2 | |
| Quinidine | 22 | −2.67 | (32) | −3.49 | −2.85 | −0.6 | |
| Quinine | 23 | −2.63 | (32) | −3.45 | −2.98 | −0.5 | |
| Quinine | 26 | −2.59 | (32) | −3.41 | −2.98 | −0.4 | |
| Risperidone | 153 | −1.81 | (35) | −2.94 | −3.78 | 0.8 | |
| Ritonavir | 3 | −3.52 | (11) | −5.52 | −4.84 | −0.7 | |
| Ritonavir | 4 | −3.41 | (45) | −5.41 | −4.84 | −0.6 | |
| Saquinavir | 5 | −3.31 | (11) | −5.22 | −5.18 | −0.1 | |
| SNC121 | 29 | −2.53 | (51) | −4.06 | −2.76 | −1.3 | |
| Sumatriptan | 0.3 | −4.60 | (35) | −5.06 | −5.03 | 0.0 | |
| Terfenadine | 47 | −2.33 | (52) | −1.87 | −0.93 | −0.9 | |
| Testosterone | 182 | −1.74 | (59) | −3.74 | −3.49 | −0.3 | |
| Testosterone | 794 | −1.10 | (53) | −3.10 | −3.49 | 0.4 | |
| Theobromine | 10 | −3.00 | (53) | −5.00 | −6.08 | 1.1 | |
| Trifluoperazine | 131 | −1.88 | (35) | −3.00 | −1.86 | −1.1 | |
| Verapamil | 47 | −2.33 | (69) | −3.10 | −1.93 | −1.2 | |
| Verapamil | 56 | −2.25 | (45) | −3.02 | −1.93 | −1.1 | |
| Zidovudine | 1 | −3.99 | (87) | −5.99 | −5.28 | −0.7 |