Morphology and LEKTI expression in the skin with Neterton syndrome (NS). (a,b) H&E staining and (c,d) immunofluorescence staining in healthy donor skin and NS skin. In NS, the acanthotic, psoriasiform epidermis was covered by parakeratotic stratum corneum (b) and LEKTI expression was absent in the uppermost layers of the skin (d), compared to healthy donor skin, where intense membranous staining (green color) was detectable in the granular and cornified layers (c). (a,b) Bar = 100 µm; (c,d) = 20 µm. LEKTI, lymphoepithelial Kazal-type-related inhibitor.