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. 2010 Oct 5;19(2):266–273. doi: 10.1038/mt.2010.211

Figure 3.

Figure 3

FREG strongly inhibits melanoma growth in a PDGF-Rα-dependent way. (a) SK-MEL-110 proliferation induced by FCS 10% (48 hours) was tested in the presence of increasing FREG concentrations. FREG inhibited melanoma cell growth in a concentration-dependent manner (*P < 0.005 versus FCS). (b) In the presence of the antibody neutralizing PDGF-Rα (0.6 µg/ml), the antimitogenic action of FREG (100 ng/ml) was significantly reverted (*P < 0.05 versus FCS; **P < 0.05 versus FCS in the presence of FREG). (c) FCS-induced melanoma cell invasion through collagen IV (10 µg/ml) was inhibited by FREG in a dose-dependent way (*P < 0.05 versus FCS). Data are expressed as mean ± SD of three independent experiments. ctrl, control; FCS, fetal calf serum; PDGF-Rα, platelet-derived growth factor-receptor-α.