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. 2010 Nov 2;19(2):293–301. doi: 10.1038/mt.2010.234

Figure 2.

Figure 2

Representative fundus photographs showing GFP expression in vivo after subretinal delivery of multiple Y-F mutant AAV2 vectors in adult mouse retinas. (a) Strong fluorescence was detectable as early as 3 weeks postinjection in eyes treated with the (Y444,500,730F) triple mutant, and remained higher for this mutant (d) than for other vectors at 10 weeks postinjection, (b) AAV2 wild type, (c) double mutant (Y444, 730F), (e) quadruple mutant (Y272,444,500,730F), (f) pentuple mutant (Y272,444,500,704,730F), (g) sextuple mutant (Y252,272,444,500,704,730F), (h) septuple mutant (Y252,272,444,500,700,704,730F). AAV2, adeno-associated virus serotype 2; GFP, green fluorescent protein.