Figure 1.

Expression of sFlt01 protein in the aqueous humor of the eye. Aqueous humor was sampled from the injected (right) eye of nonhuman primates at 1, 3, 6, 9, and 12 months postinjection of AAV2-sFLT01 from (a) group 2 (2.4 × 10⁹ vg) or from (b) group 3 (2.4 × 10¹⁰ vg). One animal in group 3 (#3603) was kept on study for an additional 6 months. At the end of the study, the eyes from animals 2009, 2103, 2603, 3009, 3603, and 3604 were dissected for vitreous collection (“vit”) and were assayed for sFlt01 expression. AAV2, adeno-associated virus type 2; vg, vector genomes.