Comparisons of retinal function in adeno-associated virus vectors of serotype 5 (AAV5), AAV8, and AAV8 (Y733F)-treated rd10 mice over time. (1) AAV5, (2) AAV8, (3) AAV8 (Y733F)-mediated gene therapy all have rescue effects 4 weeks after P14 treatment both in scotopic (upper, left) and photopic (lower, left) conditions. AAV8 and AAV8 (Y733F) both have rescue effects 8 weeks following injections (middle column). Only AAV8 (Y733F) has rescue effect 6 months following P14 treatment both in scotopic (upper, right) and photopic (lower, right) conditions.