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. 2011 Feb 1;25(3):251–262. doi: 10.1101/gad.2009211

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Figure 5. — ERG is critical for HSC maintenance. Representative examples of GFP⁺ contribution to SLAM-LSK-defined HSC populations in chimeric E14.5 liver (A), E18.5 liver (B), and adult bone marrow (C). Quantification of normalized hematopoietic chimerism by GFP⁺ embryos to HSC (SLAM-LSK) (D) and lineage⁺ (Lin⁺) (E) populations in fetal liver (E14.5 and E18.5) and adult bone marrow. Data are cumulative of three to five independent experiments: Erg^+/+ (n = 6), Erg^+/M (n = 9), and Erg^M/M (n = 5); E18.5 Erg^+/+ (n = 5), Erg^+/M (n = 7), and Erg^M/M (n = 4); and adult Erg^+/+ (n = 6) Erg^+/M (n = 8), and Erg^M/M (n = 5). For reference, overall chimerism (OC) is indicated. Plots represent mean ± SD. (*) P < 0.03; (**) P < 0.01; (***) P < 0.0001.