. 2010 Jun 29;22(3):903–910. doi: 10.1007/s00198-010-1337-8

Table 3.

Use of PPIs or H2RAs and risk of hip fracture, by daily dose

Use before	PPI	H2RA
Use before	Adjusted^a OR (95% CI)	Adjusted^a OR (95% CI)
Never	1.00	1.00
Current use	1.20 (1.04–1.40)	1.19 (1.00–1.42)
Average daily dose, DDD
First time user	1.29 (0.79–2.09)	1.40 (0.78–2.51)
<1.00	1.21 (0.93–1.57)	0.93 (0.73–1.18)^b
1.00–1.75	1.12 (0.88–1.42)	1.67 (1.21–2.31)^b
>1.75	1.35 (1.02–1.77)	1.57 (0.89–2.77)

OR odds ratio, CI confidence interval, DDD defined daily dosage

^aAdjusted for the same confounders listed in Table 2

^bWald statistic: the risk of hip fracture is statistically significantly lower among current H2RA users with <1.00 DDD compared with current H2RA users with 1.00–1.75 DDD (P < 0.05)