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. 2011 Jan 20;2010:476969. doi: 10.1155/2010/476969

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Copyright © 2010 Oliver Seitz et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wound closure and systemic effects of wounding. (a) 5-day wounds in CD-fed, HFD-fed and ob/ob mice (left panel). Distances of neoepithelia in cross-sectional areas of 5-day and 7-day wounds of CD-fed, HFD-fed and ob/ob mice (right panels). (b) Histologies showing wound neoepithelia of CD, HFD or ob/ob mice as indicated. Scale bars = 500 μm. The epithelial margins are indicated by a yellow line. Panel: areas of wound margin neoepithelia in CD, HFD and ob/ob mice. **P < .01 versus CD-fed mice. Bars indicate the mean ± SD obtained from 8 wounds (n = 8) from 4 individual animals (n = 4). (c) Serum insulin, (d) Leptin and (e) TNF-α levels in CD-fed, HFD-fed or ob/ob mice before wounding and during different days of healing as indicated. **P < .01; *P < .05 versus CD-fed mice. Each single experimental time point depicts the mean ± SD obtained from 4 individual animals (n = 4).

Wound closure and systemic effects of wounding. (a) 5-day wounds in CD-fed, HFD-fed and ob/ob mice (left panel). Distances of neoepithelia in cross-sectional areas of 5-day and 7-day wounds of CD-fed, HFD-fed and ob/ob mice (right panels). (b) Histologies showing wound neoepithelia of CD, HFD or ob/ob mice as indicated. Scale bars = 500 μm. The epithelial margins are indicated by a yellow line. Panel: areas of wound margin neoepithelia in CD, HFD and ob/ob mice. **P < .01 versus CD-fed mice. Bars indicate the mean ± SD obtained from 8 wounds (n = 8) from 4 individual animals (n = 4). (c) Serum insulin, (d) Leptin and (e) TNF-α levels in CD-fed, HFD-fed or ob/ob mice before wounding and during different days of healing as indicated. **P < .01; *P < .05 versus CD-fed mice. Each single experimental time point depicts the mean ± SD obtained from 4 individual animals (n = 4).