Figure 12.

Plasma lipid levels and lipoprotein profiles in Apoe^−/−Apob^100/100ob^−/− and Ldlr^−/−Apob^100/100ob^−/− mice. (A) Cholesterol levels in Apoe^−/−Apob^100/100ob^−/−, Ldlr^−/−Apob^100/100 ob^−/−, and C57BL/6 mice (n = 7–16). (B) Distribution of cholesterol in the plasma lipoproteins of Apoe^−/−Apob^100/100ob^−/−, Ldlr^−/−Apob^100/100 ob^−/−, and wild-type C57BL/6 mice. A total of 2–5 μl of fresh plasma was used for HPLC-fractionation of the plasma. (C) Triglyceride levels in Apoe^−/−Apob^100/100ob^−/−, Ldlr^−/−Apob^100/100ob^−/−, and C57BL/6 wild-type control mice (n = 7–18).