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. Author manuscript; available in PMC: 2011 Feb 8.
Published in final edited form as: Curr Drug Targets. 2008 Mar;9(3):174–189. doi: 10.2174/138945008783755629

Figure 2.

Figure 2

Lipoprotein sizes in Apoe−/−Apob100/100, Ldlr−/−Apob100/100, Ldlr−/−Apob+/+, and Apoe−/−Apob+/+ mice. The median diameter of lipoproteins in Apoe−/−Apob100/100 mice (n = 15) was 140% larger than in Ldlr−/−Apob100/100 (n = 21) mice, 90% larger than in Ldlr−/−Apob+/+ mice (n = 17), and 50% larger than in Apoe−/−Apob+/+ mice (n = 16). The size of VLDL (d < 1.006 g/ml) particles ranged from an average of 33.4 nm in Ldlr−/−Apob100/100 mice to 61 nm in Apoe−/−Apob100/100 mice; the size of IDL (d = 1.006–1.020 g/ml) particles ranged from an average of 27 nm in Ldlr−/−Apob100/100 mice to 38 nm in Apoe−/−Apob100/100 mice; the size of LDL (d = 1.020–1.052 g/ml) particles was 23 nm in Apoe−/−Apob100/100 plasma, 20 nm in Apoe−/−Apob+/+ plasma, 22 nm in Ldlr−/−Apob100/100 plasma, and 19 nm in Ldlr−/−Apob+/+ plasma. The difference in size between the bottom and top deciles of particles was 64.0 nm for Apoe−/−Apob100/100 mice, 27.2 nm for Apoe−/−Apob+/+ mice, 17.8 nm for Ldlr−/−Apob+/+ mice, and 17.0 nm for Ldlr−/−Apob100/100 mice. Reproduced from a paper by Véniant et al. (25) with permission from the American Society of Clinical Investigation.