Table 1.
Clinical, morphologic, and cytogenetic characteristics of patients with myelodysplastic syndrome and isolated trisomy 14.
| Age (Y) | Sex | WBC (109/L) | Hb (g/dL) | Platelet (109/L) | WHO classification | Karyotype | Cellularity (%) | Blast (%) | Trilineage dysplasia | IPSS score |
|---|---|---|---|---|---|---|---|---|---|---|
| 79 | M | 4.2 | 10.1 | 79 | RAEB-1 | 47, XY, +14 [3]/46,XY [14] | 90 | 8 | Yes | 1.0 |
| 79 | M | 1.6 | 9.2 | 75 | RAEB-2 | 47, XY, +14 [8]/46,XY [12]* | 15 | 18 | Yes | 2.5 |
| 75 | F | 4.5 | 11.2 | 38 | RAEB-1 | 47, XX, +14 [3]/46,XX [14]* | 65 | 13 | Yes | 2.0 |
| 70 | M | 3.4 | 8.1 | 23 | RAEB-2 | 46, XX, i(14)(q10) [8] | 90 | 13 | Yes | 2.5 |
| 73 | M | 3.9 | 10.0 | 351 | RARS | 46, X, -Y,+14 [3]/45, X, -Y [2]/ 46, XY [15]* | 35 | 4 | Yes | 1.0 |
| 63 | M | 8.8 | 10.8 | 465 | RARS | 46, XY, i(14)(q10) [5]/46, XY [15]* | 60 | 2 | Yes | 0.5 |
| 68 | M | 6.0 | 8.5 | 156 | RCMD | 46, XY, i(14)(q10) [16] | 95 | 1 | Yes | 0.5 |
*Diploid karyotype at time of initial diagnosis.
Y: years; M: male; F: female; WBC: white blood cell; Hb: hemoglobin; RAEB: refractory anemia with excess blasts; RARS: refractory anemia with ring sideroblasts; RCMD: refractory cytopenia with multilineage dysplasia; IPSS: international prognostic scoring system.