Table 2.
Clinical, morphologic, and cytogenetic characteristics of patients with myelodysplastic/myeloproliferative neoplasms and isolated trisomy 14.
| Age (Y) | Sex | WBC (109/L) | Hb (g/dL) | Platelet (109/L) | WHO classification | Karyotype | Cellularity (%) | Blast (%) | Trilineage dysplasia | IPSS score |
|---|---|---|---|---|---|---|---|---|---|---|
| 68 | M | 14.8 | 13.7 | 626 | CMML-1 | 47, XY, +14 [16] | 85 | 8 | Yes | 1.0 |
| 72 | M | 18.6 | 8.8 | 198 | CMML-1 | 47, XY, +14 [16] | 90 | 2 | Yes | 0.5 |
| 86 | F | 11.3 | 10.8 | 171 | CMML-1 | 47, XX, +14 [16] | 95 | 9 | Yes | 1.0 |
| 51 | F | 7.6 | 12.3 | 160 | CMML-2 | 46, XX, i(14)(q10) [16] | 35 | 17 | Yes | 2.0 |
| 77 | F | 19.2 | 9.7 | 291 | MDS/MPN-U | 47, XX, +14 [14]/46, XX [3]* | 100 | 6 | Yes | 1.0 |
*Unknown karyotype at time of initial diagnosis.
Y: years; M: male; F: female; WBC: white blood cell; Hb: hemoglobin; CMML: chronic myelomonocytic leukemia; MDS/MPN-U: myelodysplastic/myeloproliferative neoplasm, unclassifiable; IPSS: international prognostic scoring system.