Table 3.

Pressure-conductance analysis in 4 mice background strains under increasing isoproterenol. All data are expressed as mean ± standard deviation. Values marked with * are P < .05 versus previous value, ^† if P < .01 versus previous value, and ^‡ if P < .05 between 0 and 90 ng/kg/min.

	Isoproterenol (ng/kg/min)	HR (bpm)	Ves (uL)	Ved (uL)	Pes (mmHg)	Ped (mmHg)	EF (%)	CO (uL/min)	Ees	EDPVR (mmHg/μL)	PRSW (mmHg)	Efficiency (SW/PVA)
Swiss	0	623 ± 71	10.9 ± 5.1	30.7 ± 9.1	69.5 ± 9.9	1.2 ± 1.7	70 ± 11	14038 ± 4530	9.5 ± 5.0	0.265 ± 0.082	92 ± 22	0.78 ± 0.05
	3	681 ± 77†	10.3 ± 7.0	30.1 ± 9.7	65.9 ± 14.9	−2.1 ± 2.2†	72 ± 13	15832 ± 5374†	8.9 ± 4.2	0.221 ± 0.065	101 ± 18	0.79 ± 0.04
	90	720 ± 79‡	6.8 ± 5.7	24.9 ± 7.2*	56.1 ± 17.7‡	−5.1 ± 2.1*‡	79 ± 16	15537 ± 5549	9.3 ± 6.1	0.239 ± .087	82 ± 39	0.76 ± 0.050
C57BL6/J	0	569 ± 43	16.5 ± 6.2	31.8 ± 7.2	76.8 ± 8.2	1.9 ± 2.0	56 ± 13	10405 ± 2683	6.1 ± 2.1	0.218 ± 0.074	88 ± 21	0.70 ± 0.08
	3	586 ± 50*	13.6 ± 7.1*	31.2 ± 7.6	64.1 ± 9.6†	0 ± 2.5	64 ± 17†	12196 ± 3405	6.2 ± 1.8	0.216 ± 0.076	102 ± 24	0.69 ± 0.05
	90	681 ± 41*‡	4.7 ± 5.6*‡	24.7 ± 8.4‡	45.0 ± 13.8*‡	−2.8 ± 2.5*‡	88 ± 14‡	16245 ± 4818‡	11.0 ± 5.5	0.256 ± 0.084	106 ± 30	0.77 ± 0.14
DBA2	0	545 ± 40	9.0 ± 3.1	25.8 ± 7.1	71.9 ± 8.0	1.2 ± 1.2	72 ± 9	10438 ± 3251	8.4 ± 3.8	0.316 ± 0.079	94 ± 25	0.70 ± 0.13
	3	615 ± 50†	5.0 ± 3.8*	21.4 ± 3.5*	87.1 ± 23.4	−1.3 ± 1.2†	83 ± 16*	11634 ± 3246	14.7 ± 6.9†	0.266 ± 0.133	102 ± 23	0.75 ± 0.09
	90	671 ± 39‡	3.9 ± 3.0	15.3 ± 3.5†‡	61.5 ± 16.4	−4.7 ± 2.0*‡	83 ± 15	9918 ± 3574*	15.6 ± 5.8‡	0.239 ± 0.049	94 ± 27	0.74 ± 0.07
BalbC	0	566 ± 35	17.5 ± 4.6	30.0 ± 9.9	84.20 ± 13.62	2.9 ± 2.9	48 ± 6	8466 ± 3013	8.2 ± 2.9	0.415 ± 0.159	82 ± 23	0.60 ± 0.11
	3	586 ± 26*	16.4 ± 4.8	28.4 ± 9.9*	86.2 ± 8.5	2.8 ± 3.1*	49 ± 4	8464 ± 2804	8.5 ± 2.6	0.382 ± 0.113	93 ± 19*	0.63 ± 0.11
	90	733 ± 50*‡	4.9 ± 4.1‡	19.3 ± 4.5‡	61.5 ± 19.5	−2.0 ± 2.8*‡	81 ± 13‡	11760 ± 1958	11.1 ± 1.7‡	0.314 ± 0.105*‡	117 ± 6*‡	0.70 ± 0.06*‡