Fig. 3.

Developmental changes in CpG methylation and DMR extent. DNA methylation status in the gametes (oocyte, red; sperm, blue) compared with that in 12.5 dpc mouse embryos (maternal allele, red; paternal allele, blue). The extents of the DMRs shown were determined after the removal of potential clonal amplification events. Undetermined endpoints of methylation are indicated by gradient shading. Gametic DMRs containing ICs are centred and the changes in DMR extent that have occurred in embryos by 12.5 dpc are represented by pink (maternal DMRs) and light blue (paternal DMRs) areas. Major transcription start sites are indicated by arrows. DMRs were classified into four groups (enlarged, shifted, contracted and fused) according to the pattern of change in extent.