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Schematic representation of the MUC1 heterodimer positioned at the cell membrane. MUC1-N is the mucin component of the heterodimer that contains the glycosylated variable numbers of tandem repeats. MUC1-N is tethered to the cell surface through binding to the transmembrane MUC1-C subunit (left). Shedding of MUC1-N leaves MUC1-C at the cell membrane as a putative receptor for signaling the presence of extracellular stress to the interior of the cell (right).
