Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure of the MUC1-C subunit. (A) MUC1-C includes a 58 amino acid extracellular domain, a 28 amino acid transmembrane domain and a 72 amino acid cytoplasmic domain. Amino acid sequence of the MUC1-C extracellular domain is shown with highlighting of N-36 that undergoes glycosylation and functions as a galectin-3 binding site. (B) Schematic representation of the MUC1-C receptor with galectin-3 functioning as a bridge to EGFR and other cell surface molecules.
