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Intracellular targeting of MUC1-C to the nucleus and mitochondria. In transformed cells, MUC1 expression is upregulated and repositioned from the apical membrane to over the entire cell surface. In addition, MUC1-C accumulates in the cytosol and is transported to the nucleus by importin β, where it interacts with diverse transcription factors. Alternatively, MUC1-C is targeted to the mitochondrial outer membrane by HSP70/HSP90 complexes.
