Table 1.

Recombinant phage lysins targeting pathogenic bacteria

Lysin, Origin	Activity	Murine sepsis challenge*	Reference
Ply118, L. monocytogenes Φ A118	amidase	−	91
Ply511, L. monocytogenes Φ A511	amidase	−	91
Ply500, L. monocytogenes Φ A500	endopeptidase	−	29
Pal, S. pneumoniae Φ Dp-1	amidase, endopeptidase	+ (nasopharynx, oropharynx. intraperitoneal)	17, 51
Cpl-1, S. pneumoniae Φ Cpl-1	muramidase	+ (intraperitoneal, nasopharynx, mucosa, bloodstream, aortic valve)	51–53, 55
PlyGBS, GBS Φ NCTC 11261	muramidase, endopeptidase	+ (vagina, oropharynx)	64
PlyC, S. pyogenes Φ C1	amidase	+ (oral mucosa, nasal mucosa)	16, 89
GBS lysin, S. agalactiae Φ B30	muramidase, endopeptidase	−	99
LambdaSa1 prophage lysin, S. agalactiae LambdaSa1 prophage,	glycosidase	−	100
LambdaSa2 prophage lysin, S. agalactiae LambdaSa2 prophage	glycosidase, endopeptidase	−	100
Ply700, S. uberis (ATCC 700407) prophage	amidase	−	85
LySMP, S. suis Φ SMP	glycosidase, endopeptidase	−	87
PlyG, B. anthracis Φ γ	amidase	+ (intraperitoneal)	18
PlyPH, B. anthracis Ames prophage	amidase	+ (intraperitoneal)	18, 78
PlyB, B. anthracis Φ Bcp1	muramidase	−	45
Lys16, S. aureus Φ P68	endopeptidase	−	101
LysK, S. aureus Φ K	amidase, endopeptidase	−	20
Phi11 lysin, S. aureus Φ11	amidase, endopeptidase	−	74, 75
MV-L, S. aureus Φ MR11	amidase, endopeptidase	+ (nasal cavity, intraperitoneal)	33
LysH5, S. aureus Φ H5	amidase, endopeptidase	−	73
LysWMY, S. Warneri M Φ WMY	amidase, endopeptidase	−	102
Ply3626, C. perfringens Φ 3626	amidase	−	82
CD27 lysin, C. difficile Φ CD27	amidase	−	80
PlyV12, E. faecalis Φ 1	amidase	−	76
Av-1 lysin, A. naeslundi Φ Av-1	putative amidase/muramidase	−	103
LysgaY, L. gasseri Φ gaY	muramidase	−	104

^*+, Tested in vivo in murine sepsis model, with site of challenge; −, Not tested in vivo in murine sepsis model.