(b)

	Traumatic brain injury
	LFP	CCI	Weight drop
Mouse	(i) Anesthesia	(i) Anesthesia	(i) Anesthesia
	(ii) 2.0 diameter craniotomy [52]	(ii) 3–5 mm craniotomy, dura intact [53–56]	(ii) Impact on exposed skull or intact dura [57]
	(iii) Installation of a fluid percussion device [52, 58]	(iii) Installation of a pneumatically driven impactor (3 mm impounder)	(iii) 250 g metal rod dropped from 2-3 cm [59–61]:
	(iv) Impact on intact dura by a brief fluid bolus [60, 62, 63]	(iv) Velocity 5-6 m/sec; depth of 0.5–1 mm [53–56]	(a) risk of skull fractures >3 cm [60]
	(v) Injury magnitude: 3.6 atm [52]		(b) inadequate trauma <2 cm [60]
Rat	(i) Anesthesia	(i) Anesthesia	(i) Anesthesia
	(ii) Craniotomy (4 × 2 mm) [30, 64, 65]	(ii) Craniotomy (diameter 6–10 mm) [66–68]	(ii) Fixation of a steel disc [69–71]
	(iii) Installation of a luer-lock connector to intact dura [30, 64, 65]	(iii) Installation of a pneumatic cylinder [66–68]	(iii) 300–450 g weight drop from 1–1.8 m height (exposed skull) [69–71]
	(iv) Trauma induction with 2.4 bars [30, 64, 65]	(iv) Impact velocity 4–8 m/sec [66–68]	(iv) 21 g from 35 cm height (exposed dura) [72]
Pig	(i) Complex anesthesia	(i) Complex anesthesia	Commonly not performed
	(ii) Complex craniotomy [73–75]	(ii) Complex craniotomy [73–75]
	(iii) Additional ICP monitoring [73–75]	(iii) Additional ICP monitoring [73–75]
	(iv) Trauma induction with 3–8 bars [73, 75]	(iv) Injury induction on intact dura:
		(a) velocity of 3.5 m/sec [76, 77]
		(b) dwell time 400 ms [76, 77]