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. Author manuscript; available in PMC: 2012 Jan 15.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 10;21(2):638–643. doi: 10.1016/j.bmcl.2010.12.036

Scheme 2 — Synthesis of pyrrolopyrimidine compound 2a (a) (i) NIS, CH₂Cl₂; (ii) NaH, SEM-Cl, DMF (b) Pyridine-3-boronic acid, Pd(dppf)Cl₂, dppf, Na₂CO₃(aq)/Dioxane (1:2) (c) 3-Boc-aminophenol, K₂CO₃, DMSO, 100^oC (d) (i) TFA, CH₂Cl₂; (ii) acryloyl chloride, DIEA, CH₂Cl₂; (iii) NaHCO₃(aq), THF.