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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 10;21(2):638–643. doi: 10.1016/j.bmcl.2010.12.036

Scheme 3.

Scheme 3

Synthesis of pyrimidine compound 3h (a) K2CO3, DMF (b) 4-(4-methylpiperazin-1-yl) aniline, TFA, 2-BuOH, 100oC (c) PtO2, H2, MeOH (d) acryloyl chloride, DIEA, CH2Cl2.