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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 10;21(2):638–643. doi: 10.1016/j.bmcl.2010.12.036

Table 4.

Cellular antiproliferative data

graphic file with name nihms258384u4.jpg
Compd X Cellular antiproliferative Activity (EC50, uM)
EGFR del Del/T790M
3h Cl 0.015 0.003
5a H 0.08 >1
5b CF3 0.70 0.80
5c Br 0.80 0.90