Table 1.
IC50 values of antibiotics for the 16S and 18S A-sitesa
| Antibiotics | 16S A-Site/ 10−6 M |
18S A-Site/ 10−6 M |
Selectivity ratio |
|---|---|---|---|
| Neomycin B | 2.8 (± 0.3) | 4.7 (± 0.2) | 0.60 |
| Tobramycin | 20.2 (± 0.4) | 19.5 (± 0.3) | 1.0 |
| Paromomycin | 9 (± 1) | 8.0 (± 0.6) | 1.1 |
| Kanamycin A | 75 (± 3) | 46 (± 2) | 1.6 |
| Amino-tobramycin | 4.2 (± 0.4) | 3.8 (± 0.4) | 1.1 |
| Amino-kanamycin A | 11.9 (± 0.4) | 4.7 (± 0.3) | 2.5 |
| Negamycin | 62 (± 5) | 42 (± 3) | 1.5 |
| Neamine | 18 (± 2) | 6 (± 1) | 3 |
| Erythromycin | 1880 (± 10) | 1750 (± 10) | 1.1 |
| Lincomycin | > 8.5 × 103 | > 8.5 × 103 | — |
| Linezolid | > 9.6 × 103 | > 9.6 × 103 | — |
a
Conditions as listed in Fig. 5.