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Analgesia assessed with the tail flick test. (A,B) Time course of latency to respond presented as group means ± SEM for rhes+/+ (A) and rhes−/− (B) mice. (C) Dose-response curves for analgesia assessed at 45 minutes post-morphine injection, showing a threefold leftward shift in the ED50 value of rhes+/+ mice relative to rhes−/− mice. n = 5 for 0, 0.3, and 1 mg/kg, n= 9–11 for 3 and 10 mg/kg.
