TABLE 2.
Pathways and lipid metabolism genes impacted by the overexpression of HA-FoxO4 in serum starved Puro versus HA-FoxO4 cells
| Ontology Group | Z Score |
|---|---|
| Sterol biosynthesis | 11.9 |
| Sterol metabolism | 10.6 |
| Cholesterol biosynthesis | 8.8 |
| Steroid biosynthesis | 8.7 |
| Cholesterol metabolism | 8.5 |
| Mitotic cell cycle | 8.4 |
| Mitosis | 8.4 |
| Positive regulation of progression through cell cycle | 8.3 |
| M phase of mitotic cell cycle | 8.3 |
| Lipid biosynthesis | 5.5 |
| Fatty acid elongation | 4.0 |
| Fatty acid desaturation | 3.0 |
| Fatty acid biosynthesis | 2.8 |
| Cholesterol Biosynthesis | Fold increase in HA-FoxO4 vs. Puro |
| Hydroxymethylglutaryl CoA synthase (HMGCS1) | 10.9 |
| Hydroxymethylglutaryl CoA reductase (HMGCR) | 9.9 |
| Isopentenyl diphosphate δ isomerase (IPDI) | 39.2 |
| Farnesyl diphospho transferase (FDFS1) | 6.3 |
| NADP-dependent steroid dehydrogenase (NADPSD) | 5.8 |
| Δ-24 sterol reductase (DHCR24) | 3.4 |
| Lanosterol 14α demethylase (CYP51) | 1.3 |
| SREBP2 | 3.6 |
| Fatty Acid Biosynthesis, Elongation, and Desaturation | |
| Acetyl-CoA Carboxylase (ACC1) | 1.6 |
| Fatty Acid Synthase (FASN) | 3.1 |
| Long-chain fatty-acyl elongase (ELOVL6) | 5.9 |
| Stearoyl-CoA Desaturase 1 (SCD1) | 4.0 |
| Stearoyl-CoA Desaturase 2 (SCD2) | 4.7 |