TABLE 1.
Summary of QTLs identified for HDL-C by genome-wide linkage analysis
| QTL for HDL-Ca | Number of Families | LOD Score | Study |
|---|---|---|---|
| 2q21.3 | 330 families (Framingham Heart Study) | 3.5 | Arya et al. (44) |
| 4q21.21 | 13 French-Canadian families | 4.6 | Yu et al. (29) |
| 5p13.3 | 101 Caucasian families (NHLBI Study) | 3.6 | Peacock et al. (31) |
| 6q23.1 (HDL3-C) | 330 families (Framingham Heart Study) | 4.0 | Yang et al. (45) |
| 7p15-22 | 388 Caucasian families (GeneQuest) | 3.76 | Present study |
| 7q31.32 | 295 African-American diabetic sib pairs | 4.3 | Adeyemo et al. (46) |
| 8q23.1-24.22 | 25 Finnish families | 4.7 | Soro et al. (33) |
| 8q23.1-24.22 | 10 Mexican-American families (San Antonio Heart Study) | 4.9 | Almasy et al. (30) |
| 9p21.3 | 27 Mexican-American families | 3.4 | Arya et al. (47) |
| 11q23.3 | 105 families from Utah | 3.5 | Kort et al. (48) |
| 12q14.1 | 292 pedigrees (Quebec Family Study) | 4.1 | Bosse et al. (49) |
| 15q22.31b | 10 Mexican-American families (San Antonio Heart Study) | 3.3 | Almasy et al. (30) |
| 15q21-26 | 388 Caucasian families (GeneQuest) | 6.69 | Present study |
| 16q22.3-23.1 | 10 Mexican-American (San Antonio Heart Study) | 4.3 | Mahaney et al. (50) |
| 16q22.3-23.1 | 48 Dutch and Finnish families | 3.4 | Pajukanta et al. (51) |
Abbreviations: HDL-C, high density lipoprotein cholesterol; LOD, logarithm of odds; NHLBI, National Heart, Lung, and Blood Institute; QTL, quantitative trait locus.
a
Chromosome location.
b
Unesterified HDL2a-C.