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. 2010 Jun;51(6):1513–1523. doi: 10.1194/jlr.M004812

Fig. 5.

Fig. 5.

Effect of miR-370 on Cpt1α expression in HepG2 cells. A: Target sequence in the 3′ UTR of Cpt1α for miR-370. B: Effect of miR-370 on the activity of the SV40 luciferase construct linked to the 3′ UTR of Cpt1α. C: Cpt1α mRNA levels assessed by real-time PCR analysis 24 h and 48 h post-transfection of HepG2 cells with 50 nM miR-370 or miR-122. D: Fatty acid β oxidation levels following transfection of HepG2 cells with 50 μM of miR-370. Statistically significant differences relative to the controls are indicated by asterisks in panels B, C, and D. ACC1, acyl-CoA carboxylase 1; dn-cJun, dominant negative cJun; Cpt1α, carnitine palmitoyl transferase 1α; DGAT2, diacylglycerol acyltransferase-2; miR, microRNA; SREBP-1c, sterol-regulatory element binding protein 1c; UTR, untranslated region.