TABLE 2.
Percent change from baseline in LDL-C, HDL-C, and apoA-I across dose range for each statin
| Least-squares mean % change from baseline (SE) |
|||||
|---|---|---|---|---|---|
| Dose (mg) | na | LDL-C | HDL-C | ApoA-I | |
| Rosuvastatin | 5 | 670 | −38.8 (0.9) | 5.5 (0.8) | 6.0 (0.7) |
| 10 | 11,690 | 44.1 (0.6) | 6.1 (0.5) | 6.5 (0.4) | |
| 20 | 3,554 | 49.5 (0.5) | 7.0 (0.4) | 6.0 (0.4) | |
| 40 | 2,983 | 54.7 (0.4) | 7.9 (0.4) | 6.4 (0.5) | |
| Atorvastatin | 10 | 7,837 | 35.5 (0.6) | 4.5 (0.5) | 4.7 (0.4) |
| 20 | 3,908 | 41.4 (0.5) | 3.5 (0.5) | 3.2 (0.4) | |
| 40 | 1,324 | 46.2 (0.5) | 2.4 (0.5) | 2.2 (0.6) | |
| 80 | 2,072 | 50.2 (0.4) | 2.3 (0.4) | 0.1 (0.6) | |
| Simvastatin | 10 | 165 | 27.4 (1.4) | 4.2 (1.3) | 5.2 (1.3) |
| 20 | 2,929 | 33.0 (0.6) | 5.0 (0.6) | 5.2 (0.5) | |
| 40 | 548 | 38.9 (0.9) | 5.0 (0.8) | 6.4 (0.8) | |
| 80 | 479 | 45.0 (1.0) | 5.3 (0.9) | 5.9 (0.9) | |
a
For approximately 35% patients, apoA-I was not available.