Figure 4.

Effect of SMe1EC2 on Fe²⁺/ascorbic acid induced protein carbonyl formation in brain cortex. Rat brain cortex homogenates (n=5–6 samples in each group) from 5–6 rats were used. The content of protein carbonyl groups was determined spectrophotometrically. The content of carbonyls in the presence of the pro-oxidative system without the drug tested was considered 100% (Ox+0). Inhibitory effect of the antioxidant tested was monitored (Ox+0.1; Ox+1; Ox+3 µmol/l of SMe1EC2). Significant difference in protein carbonyl content between the untreated oxidation modified brain cortex homogenates and the treated oxidation modified homogenates was calculated by Student' t-test, *p<0.05.