Skip to main content
. Author manuscript; available in PMC: 2011 Feb 8.
Published in final edited form as: J Biol Chem. 2006 Jul 12;281(36):26665–26674. doi: 10.1074/jbc.M602174200

FIGURE 1. Dose-dependent PAR-induced aggregation of human platelets.

FIGURE 1

Washed human platelets were stimulated with increasing concentrations of PAR1-AP or PAR4-AP. Maximal aggregation was measured in response to agonist stimulation. PAR1-AP aggregation response curve ranged from 0.1 to 100 μm, whereas the PAR4-AP aggregation response curve ranged from 1 to 800 μm. Each point on the curve is representative of the average of at least three independent experiments ± S.E. EC50 for PAR1-AP and PAR4-AP was 3 and 80 μm, respectively.