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. 2011 Feb 8;9(2):e1000590. doi: 10.1371/journal.pbio.1000590

Figure 3. Transcription of sex determination and dosage compensation genes.

Figure 3

The events in the sex determination pathway in our data are consistent with previous studies. (A) Expression levels (normalized reads per kb, RPKM) for the X chromosome signal elements (XSEs; sisA, sisB, and run) in female embryos reach twice the transcript abundance of male embryos (light blue line) near cycle 12. These factors activate Sxl expression (B) in females, with significant female expression levels around cycle 13, the presence of which interferes with msl-2 expression (C), the male-specific protein of the MSL-mediated dosage compensation, which is higher in males, starting mid-late cycle 14.