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. 2011 Mar;52(3):499–508. doi: 10.1194/jlr.M012724

Fig. 2.

Fig. 2.

Histology: effects of OVA sensitization and D-4F on pulmonary inflammation and collagen deposition. A: Representative H and E images of sections of lungs from control, nonsensitized C57BL/6J mice (upper left) and OVA-sensitized C57BL/6J mice (lower left). Treatment of OVA-Sen mice with 4F reduced infiltration of inflammatory cells into the lung parenchyma (upper right panel vs. lower right panel). B: Representative McLetchie's trichrome images of sections of lungs isolated from control, nonsensitized C57BL/6J mice (upper right) and OVA-sensitized C57BL/6J mice (lower right). 4F treatments decreased collagen deposition in the OVA-Sen mice (upper right panel vs. lower right panel). These images show that PBS and 4F treatments have little effect on airway inflammation or collagen deposition in normal C57BL/6J mice (upper images) (n = 4–6, per condition).