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. 2011 Jan 27;3(1):15–23. doi: 10.4254/wjh.v3.i1.15

Table 1.

Clinical characteristics of patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma with or without multicentric occurrence

HCC with MO
 HCC without MO
Case 1 2 3 4 5 6 7 8 9 10 11 12
Age at Dx of NASH 73 81 78 71 68 75 71 80 75 78 81 66
Gender F M M F M F M F F M M M
History of BTF - - - - - - - + - - - -
BMI (kg/m2) 31.0 26.3 25.5 32.0 26.8 23.0 27.0 32.1 34.0 23.1 24.5 25.2
T2DM + + + + - + + - + - - -
Hypertension + + + + - - - + + - + +
Dyslipidemia - - - + - + + + - + + -
Varices - - - - + - + - + - - -
Ascites - - - - - - - - - - - -
AST (IU/L) 91 67 43 33 34 43 36 34 43 25 83 78
ALT (IU/L) 46 48 49 21 17 32 22 33 40 20 37 75
γ-GTP (IU/L) 122 129 418 72 30 222 46 67 73 104 360 279
Total bilirubin (mg/dL) 1.0 0.7 0.8 1.1 1.4 1.1 1.5 0.6 1.2 0.6 0.6 0.8
Albumin (g/dL) 3.8 3.7 3.4 2.9 3.3 4.0 2.9 4.1 3.7 3.8 3.4 4.2
Prothrombin time (%) 53 72 97 62 69 NAa 59 69 86 75 84 NAa
Platelet (× 104/μL) 21.1 12.3 10.4 11.2 4.5 14.5 6.4 31.6 11.7 12.1 26.4 11.4
Child-Pugh score A A A B B -a B A A A A -a
HBsAg - - - - - - - - - - - -
Anti-HBc + - - + - - - - + + - +
Anti-HCV - - - - - - - - - - - -
Histological features (Classification by Brunt)
Grade 2 2 2 2 1 2 2 1 1 1 2 2
Stage 4 4 4 4 4 4 4 4 4 1 2 4
Type of cirrhosis Mixed Mixed Macro Mixed Micro Mixed Mixed Mixed Mixed - - Macro
AFP (ng/mL) 11 26 15 25 7 9 3 8 757 12 2 963 900 100 8
DCP (mAU/mL) 18 24 20 116 24 NAa 14 35 907 131 10 700 NAa
Maximum size of HCC (mm) 35 50 40 28 22 17 50 26 40 40 110 70
Number of HCC Mul Mul Mul Mul Mul Sol Mul Sol Mul Mul Mul Sol
TNM stage III III III III IVA I III II III IVB III II
Initial treatment Ope TACE Ope TACE TAI RFA TACE TACE Ope Chemo Ope TAI
+ RFA + RFA + Ope + RFA + Ope
Outcome Alive Dead Dead Alive Alive Alive Alive Alive Dead Dead Alive Alive
Cause of death - LR NLR - - - - - LR LR - -
Follow-up period after Dx of HCC (days) 2 599 1 706 288 1 140 280 1 011 687 2 198 1 525 489 162 330

HCC: hepatocellular carcinoma; MO: multicentric occurrence; Dx: diagnosis; BTF: blood transfusion; BMI: body mass index; M: Male; F: Female; T2DM: type 2 diabetes mellitus; AST: aspartate aminotransferase; ALT: alanine aminotransferase; γ-GTP: γ-glutamyltranspeptidase; NA: not available; AFP: alpha-fetoprotein; DCP: des-γ-carboxy-prothrombin; Mixed: mixed nodular cirrhosis; Macro: macronodular cirrhosis; Micro: micronodular cirrhosis; Mul: multiple; Sol: solitary; TACE: transcatheter arterial chemoembolization; TAI: transcatheter arterial infusion chemotherapy; RFA: radiofrequency ablation; Ope: operation; LR: liver-related death; NLR: non-liver-related death;

a

An oral administration of warfarin prevented the evaluation.