Table 3.
Adjusteda pooled odds ratios (95% confidence intervals) for melanoma in women in relation to sunburn, stratified by anatomical site of melanoma
| Head & Neckb | Trunkb | Lower Limbsb | Upper Limbsb | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases/controls | No. of studies | p OR (95% CI) | Cases/controls | No. of studies | p OR (95% CI) | Cases/controls | No. of studies | p OR (95% CI) | Cases/controls | No. of studies | p OR (95% CI) | |
| ‘Painful’ sunburn | ||||||||||||
| Never | 36/575 | 1.00 | 84/575 | 1.00 | 139/575 | 1.00 | 63/575 | 1.00 | ||||
| Ever | 94/1251 | 4 | 1.33 (0.80–2.20) | 248/1251 | 4 | 1.36 (1.00–1.87) | 295/1251 | 4 | 1.33 (1.00–1.75) | 188/1251 | 4 | 1.42 (0.66–3.04)* |
| Never | 1.00 | 1.00 | ||||||||||
| 1–5 | 39/477 | 3 | 1.23 (0.67–2.29) | 117/604 | 4 | 1.32 (0.93–1.86) | 131/604 | 4 | 1.11 (0.81–1.52) | 4 | 1.28 (0.84–1.94) | |
| 6–25 | 29/470 | 3 | 2.83(0.48–16.56)* | 86/470 | 3 | 1.28 (0.84–1.96) | 106/478 | 4 | 1.70 (1.13–2.54) | 2 | 1.99 (1.11–3.55) | |
| 26+ | 100/12 | 1 | - | 36/109 | 2 | 2.28 (1.25–4.15) | 40/116 | 3 | 3.50 (1.90–6.46) | 1 | - | |
| Trend p<0.001 | Trend p=0.001 | Trend p<0.001 | Trend p<0.001 | |||||||||
| ‘Severe’ sunburn | ||||||||||||
| Never | 81/555 | 1.00 | 157/692 | 1.00 | 235/767 | 1.00 | 98/679 | 1.00 | ||||
| Ever | 158/1182 | 8 | 1.02 (0.73–1.44) | 591/2440 | 10 | 1.25 (0.97–1.62) | 673/2474 | 11 | 1.36 (1.07–1.72) | 312/2087 | 9 | 1.21 (0.88–1.66) |
| Never | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| 1–5 | 91/535 | 5 | 0.90 (0.61–1.32) | 281/1048 | 9 | 1.26 (0.96–1.66) | 267/1096 | 10 | 1.19 (0.91–1.55) | 150/1045 | 9 | 1.17 (0.84–1.63) |
| 6–25 | 24/127 | 2 | 1.25 (0.50–3.14) | 155/678 | 8 | 1.59 (1.02–2.49) | 183/677 | 8 | 1.86 (1.22–2.84) | 99/198 | 4 | 1.99 (1.12–3.53) |
| 26+ | 13/29 | 2 | 2.41 (0.95–6.11) | 100/302 | 4 | 1.57 (0.84–2.93) | 106/306 | 4 | 1.94 (1.03–3.68) | 25/100 | 1 | - |
| Trend p<0.001 | Trend p<0.001 | Trend p<0.001 | Trend p<0.001 | |||||||||
| ‘Severe’ sunburn in youth | ||||||||||||
| Never | 116/942 | 1.00 | 375/1470 | 1.00 | 493/1632 | 1.00 | 177/1257 | 1.00 | ||||
| Ever | 57/761 | 4 | 1.33 (0.83–2.13) | 190/826 | 6 | 1.25 (0.96–1.63) | 209/809 | 8 | 1.92 (1.48–2. 50) | 139/786 | 5 | 1.54 (0.98–2.40) |
| Never | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| 1–5 | 25/442 | 3 | 1.01 (0.54–1.89) | 96/472 | 4 | 1.11 (0.80–1.54) | 114/486 | 6 | 1.73 (1.26–2.38) | 58/439 | 3 | 1.52 (0.64–3.65) |
| 6+ | 24/260 | 2 | 3.36 (1.53–7.38) | 74/274 | 3 | 1.60 (1.08–2.40) | 64/278 | 3 | 2.24 (1.41–3.56) | 55/253 | 1 | - |
| Trend p<0.001 | Trend p<0.001 | Trend p<0.001 | Trend p<0.001 | |||||||||
| Solar keratoses | ||||||||||||
| None | 13/100 | 1.0 | 23/53 | 19/100 | 13/100 | |||||||
| Any | 19/28 | 2 | 4.91 (2.11–11.46) | 25/14 | 1 | - | 21/14 | 1 | - | 15/14 | 1 | - |
*
Significant heterogeneity, random effects model used (see text).
a
Adjusted for age, sunlamp use and history of sunbathing
b
Numbers may not sum to total because of missing data