Table 5.
Adjusteda pooled odds ratios (95% confidence intervals) for melanoma in women in relation to sunburn, stratified by hair colour (red vs. other)
| Red hairb | Other hair colourb | |||||
|---|---|---|---|---|---|---|
| Cases/controls | No. of studies | p OR (95% CI) | Cases/controls | No. of studies | p OR (95% CI) | |
| ‘Painful’ sunburn | ||||||
| Never | 60/78 | 1.00 | 263/497 | 1.00 | ||
| Ever | 136/122 | 4 | 1.28 (0.76–2.14) | 693/1125 | 4 | 1.44 (0.85–2.46)* |
| Never | 1.00 | |||||
| 1–5 | 57/57 | 3 | 1.20 (0.69–2.12) | 296/536 | 4 | 1.24 (0.69–2.24)* |
| 6–25 | 13/9 | 2 | 1.99 (0.77–5.20) | 267/446 | 4 | 1.54 (1.16–2.06) |
| 26+ | 0 | - | 105/103 | 3 | 2.90 (1.89–4.44) | |
| Trend p=0.43 | Trend p<0.001 | |||||
| ‘Severe’ sunburn | ||||||
| Never | 138/93 | 1.00 | 483/668 | 1.00 | ||
| Ever | 197/158 | 6 | 0.85 (0.57–1.26) | 1591/2198 | 11 | 1.43 (1.19–1.72) |
| Never | 1.00 | 1.00 | ||||
| 1–5 | 142/108 | 5 | 0.84 (0.55–1.30) | 670/956 | 10 | 1.26 (1.03–1.54) |
| 6–25 | 34/23 | 3 | 1.29 (0.59–2.85) | 436/620 | 9 | 1.81 (1.30–2.51) |
| 26+ | 0 | - | 297/281 | 5 | 2.20 (1.41–3.44) | |
| Trend p=0.95 | Trend p<0.001 | |||||
| ‘Severe’ sunburn in youth | ||||||
| Never | 254/204 | 1.00 | 1135/1608 | 1.00 | ||
| Ever | 110/81 | 6 | 1.16 (0.73–1.84) | 520/766 | 9 | 1.57 (1.29–1.90) |
| Never | 1.00 | 1.00 | ||||
| 1–5 | 55/35 | 4 | 1.33 (0.71–2.49) | 267/479 | 7 | 1.28 (1.02–1.60) |
| 6+ | 25/22 | 1 | - | 205/266 | 5 | 1.96 (1.47–2.60) |
| Trend p=0.78 | Trend p<0.001 | |||||
| Solar keratoses | ||||||
| None | 0 | 95/144 | 1.00 | |||
| Any | 0 | 75/28 | 2 | 3.68(1.13–12.00)* | ||
*
Significant heterogeneity, random effects model used (see text).
a
Adjusted for sunlamp use and history of sunbathing
b
Numbers may not sum to total because of missing data