Table 6.
Adjusteda pooled odds ratios (95% confidence intervals) for melanoma in women in relation to sunburn, stratified by age at diagnosis of melanoma (<50 years, ≥50 years)
| Women <50 years | Women ≥ 50 years | |||||
|---|---|---|---|---|---|---|
| Cases/controls | No. of studies | p OR (95% CI) | Cases/controls | No. of studies | p OR (95% CI) | |
| ‘Painful’ sunburn | ||||||
| Never | 154/315 | 1.00 | 171/260 | 1.00 | ||
| Ever | 561/861 | 4 | 1.58(0.91–2.73)* | 270/390 | 4 | 1.17 (0.87–1.57) |
| Never | 1.00 | 1.00 | ||||
| 1–5 | 213/377 | 4 | 1.32 (0.97–1.79) | 152/227 | 4 | 1.06 (0.76–1.47) |
| 6–25 | 242/371 | 4 | 2.01 (1.41–2.86) | 67/105 | 3 | 1.17 (0.72–1.90) |
| 26+ | 95/81 | 2 | 4.78 (2.73–8.35) | 21/27 | 2 | 1.55 (0.69–3.48) |
| Trend p<0.001 | Trend p=0.14 | |||||
| ‘Severe’ sunburn | ||||||
| Never | 237/334 | 1.00 | 389/433 | 1.00 | ||
| Ever | 1179/1608 | 11 | 1.28 (0.99–1.65) | 770/866 | 11 | 1.31 (0.92–1.64) |
| Never | 1.00 | 1.00 | ||||
| 1–5 | 454/668 | 10 | 394/428 | 10 | 1.16 (0.90–1.48) | |
| 6–25 | 368/502 | 8 | 1.21 (0.92–1.58) | 157/178 | 8 | 1.24 (0.81–1.90) |
| 26+ | 252/219 | 5 | 2.06 (1.11–3.84) | 94/96 | 4 | 1.34 (0.70–2.58) |
| Trend p<0.001 | Trend p<0.001 | |||||
| ‘Severe’ sunburn in youth | ||||||
| Never | 583/900 | 1.00 | 582/648 | 1.00 | ||
| Ever | 469/633 | 8 | 1.91 (1.52–2.40) | 155/208 | 6 | 1.14 (0.83–1.57) |
| Never | 1.00 | 1.00 | ||||
| 1–5 | 240/384 | 7 | 1.68 (1.29–2.19) | 84/125 | 4 | 1.03 (0.70–1.53) |
| 6+ | 200/232 | 5 | 2.66 (1.90–3.74) | 35/66 | 3 | 0.86 (0.50–1.48) |
| Trend p<0.001 | Trend p=0.56 | |||||
| Solar keratoses | ||||||
| None | 45/63 | 1.00 | 39/52 | 1.00 | ||
| Any | 18/2 | 1 | - | 66/24 | 2 | 3.47 (1.69–7.12) |
*
Significant heterogeneity, random effects model used (see text).
a
Adjusted for age, sunlamp use and history of sunbathing
b
Numbers may not sum to total because of missing data