Table 1.
Overview of known MiHA used as a test set in this study. It displays the epitope name and the HLA-molecule it is presented in. In addition, its immunogenicity is indicated together with the gene name and the polymorphisms are indicated. aNames according to http://www.lumc.nl/dbminor
| Epitope namea / HLA | Sequence | Remarks | Gene | polymorphic AA | dnSNP entry |
|---|---|---|---|---|---|
| HA1 / A2 | VLHDDLLEA | immunogenic | HMHA1 | VL[R/H]DDLLEA | rs1801284 |
| HA2 / A2 | YIGEVLVSV | immunogenic | MYO1G | YIGEVLVS[V/M] | rs61739531 |
| HA3 / A1 | VTEPGTAQY | immunogenic | AKAP13 | V[M/T]EPGTAQY | rs2061821 |
| HA8 / A2 | RTLDKVLEV | immunogenic | KIAA0020 | [R/P]TLDKVLE[V/I] | rs2270891 |
| HA1 / B60 | KECVLHDDL | immunogenic | HMHA1 | KECVL[R/H]DDL | rs1801284 |
| LB-ADIR-1 F / A2 | SVAPALALFPA | immunogenic; ARF in 5’UTR | TOR3A (ADIR) | SVAPALAL[F/S]PA | rs2296377 |
| LB-ADIR-1 S / A2 | SVAPALALSPA | allelic counterpart | |||
| CTSHr / A31 | ATLPLLCAR | immunogenic | CTSH | ATLPLLCA[G/R] | rs2289702 |
| CTSHr / A33 | WATLPLLCAR | immunogenic | CTSH | WATLPLLCA[G/R] | rs2289702 |
| ACC1y / A24 | DYLQYVLQI | immunogenic | BCL2A1 | DYLQ[C/Y]VLQI | rs1138357 |
| ACC1c / A24 | DYLQCVLQI | immunogenic | |||
| ACC1c+ cystinylated | DYLQCVLQI | immunogenic | |||
| HB1h / B44 | EEKRGSLHVW | immunogenic | HMHB1 | EEKRGSL[H/Y]VW | rs161557 |
| ACC2d / B44 | KEFEDDIINW | immunogenic | BCL2A1 | KEFED[G/D]IINW | rs3826007 |
| ACC2g / B44 | KEFEDGIINW | allelic counterpart | |||
| LB-ECGF1-1 H/B7# | RPHAIRRPLAL | immunogenic; ARF | TYMP (ECGF1) | RP[H/R]AI[R/C]RPLAL | no entry; rs1061205 |