Table 3.

Fibrosis evaluated by collagen staining of heart sections

Group	Collagen (%)	Normal structure	I	II	III	Necrosis
Female Sham (n = 4)	2.83 ± 0.42	4	0	0	0	0
Female Ang II (n = 4)	4.15 ± 0.47a	0	2	1	1	3
Male Sham (n = 4)	3.00 ± 0.13	4	0	0	0	0
Male Ang II (n = 4)	4.36 ± 0.92a	0	0	1	3	1

Quantification of collagen content in heart sections expressed in % of cross-section area. Number of hearts allocated to in each scoring category by semi-quantification

^a P < 0.05 Ang II versus sham

Normal Normal structure, I Focal thin collagen bundles only, II Increased amounts of diffuse thin collagen bundles, III Areas of thick bundles of collagen in addition to increased thin bundles