Figure 5.

Peptide 234 inhibition of plasma LH in male mice. A, Two infusions of 15 nmol of peptide 234 inhibit the elevated LH levels of castrated male mice. B, Dose–response graph for castrated male mice given two infusions of peptide 234 indicates that all three doses tested are able to inhibit the postcastration rise in LH. C, Likewise, a single infusion of 5 or 15 nmol of peptide 234 potently inhibits LH levels of castrated mice. D, Exogenously administered kisspeptin (100 fmol) is unable to stimulate LH levels in intact male mice when 100 pmol peptide 234 is infused 5 min beforehand (n = 6–8). Bars show mean ± SEM (*p < 0.05).