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Mean arterial pressure (MAP), heart rate, fasting blood glucose concentration, and plasma insulin in (a) PC2+/+ and −/− mice on the normal-(NSD) or high-sodium diet (HSD) and in (b) Mc3r+/+ and −/− mice. While ingesting the HSD, both knockout strains developed fasting hyperglycemia and hyperinsulinemia in association with hypertension. N = 5 mice/group; *P < 0.003 or greater vs. the other groups by two-way analysis of variance.
